Station 26 was dispatched to the 400 block of Wiggins Mill Rd. for a MVC with a unconscious subject. After Res/Eng 26 made the response the incident was upgrade with the vehicle in Water. Stations 1/27 and 4/24 was alerted for the marine units. On arrival Res/Eng 26 had a pick-up off the road way and into the Appoquinimink River 100' downstream of the Wiggins Mill Pound spillway.